Different Transcutaneous Auricular Vagus Nerve Stimulation Parameters Modulate the Anti-Inflammatory Effects on Lipopolysaccharide-Induced Acute Inflammation in Mice (citation: Go 2022)

Read more about a successful study to determine the effective anti-inflammation capacity of transcutaneous auricular vagus nerve stimulation (taVNS) through development of a stimulating electrode system of transcutaneous auricular VN. Citation: Go YY, Ju WM, Lee CM, Chae SW, Song JJ. Different Transcutaneous Auricular Vagus Nerve Stimulation Parameters Modulate the Anti-Inflammatory Effects on Lipopolysaccharide-Induced Acute Inflammation in Mice. Biomedicines. 2022;10(2):247. Published 2022...


Auricular Neuromodulation for Mass Vagus Nerve Stimulation: Insights From SOS COVID-19 a Multicentric, Randomized, Controlled, Double-Blind French Pilot Study

Acute inflammation can turn chronic, as shown in studies such as reported by Harvard Medical School in a special report on Fighting Inflammation: How to stop the damage before it compromises your health. In fact, an exacerbated inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is believed to be one of the major causes of the morbidity and mortality of the coronavirus disease 2019 (COVID-19). However, inflammation that turns chronic can become a re...


Vagus Nerve Stimulation for Posttraumatic Stress Disorder in 2021 review by the Psychological Health Center of Excellence of the Department of Defense

The Psychological Health Center of Excellence of the Defense Health Agency in the Department of Defense has released a Psych Health Evidence Brief on the use of vagus nerve stimulation (VNS) for Posttraumatic Stress Disorder (PTSD). Although the 2021 brief falls short of recommending VNS for treatment of PTSD, it shows recognition of a treatment approach that is gaining rapid momentum even just since 2020.[1] In fact, transcutaneous auricular vagus nerve stimulation (taVNS) is treatment ap...


Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases. Citation: (Bonaz 2021)

A review of the potential of vagus nerve stimulation (VNS) for inflammatory bowel disease (IBD), concludes that targeting the anti-inflammatory properties of the vagus nerve with VNS could be of interest in the management of patients with IBD involving the digestive tract through a non-drug therapy. About 1.5 million Americans and 2.2 million people in Europe are affected by IBD. There is a rising incidence of IBD in Western countries, supporting the hypothesis that “Westernization” of our li...


Stress and Tinnitus; Transcutaneous Auricular Vagal Nerve Stimulation Attenuates Tinnitus-Triggered Stress Reaction. Citation: (Ylikoski 2020)

Tinnitus can become a strong stressor for some individuals, and lead to an imbalance of the autonomous nervous system resulting in reduced parasympathetic activity which may manifest as sleep disturbances, anxiety and even depression. Transcutaneous auricular Vagus Nerve Stimulation (taVNS) has been shown to activate the vagal pathways, and a therapeutic alternative in health conditions such as tinnitus-related mental stress (TRMS). In a retrospective study of 171 TRMS patients, suffering fro...


Non-invasive Auricular Vagus Nerve Stimulation as a Potential Treatment for Covid19-Originated Acute Respiratory Distress Syndrome. Citation: (Kaniusas 2020)

COVID-19 is an infectious disease caused by an invasion of the alveolar epithelial cells by coronavirus 19. The most severe outcome of the disease is the Acute Respiratory Distress Syndrome (ARDS) combined with hypoxemia and cardiovascular damage. ARDS and co-morbidities are associated with inflammatory cytokine storms, sympathetic hyperactivity, and respiratory dysfunction. The authors present and justify a novel potential treatment for Covid19-originated ARDS and associated co-morbidities, ...


Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice. Citation: (Yap 2020)

Several studies investigating the use of transcutaneous vagus nerve stimulation (tVNS) for disorders tinnitus, migraine and pain show therapeutic effects similar to those produced by the more invasive direct vagus nerve stimulation (VNS). Although VNS is an FDA-approved therapy for the treatment of both depression and epilepsy, it is limited to being a second or third-line treatment option for severe, intervention-resistant cases, due to risks involved with device implantation. In contrast, t...


Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression

Review article on the potential of transcutaneous auricular vagus nerve stimulation (taVNS) in managing depression — and as it possibly relates to pain and other chronic conditions affected by negative emotional affect and psychological conditions such as depression.   Reference: Liu, CH., Yang, MH., Zhang, GZ. et al. Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression. J Neuroinflammation 17, 54 (2020). https://doi.org/10.1186/s1...


The anatomical basis for transcutaneous auricular vagus nerve stimulation. Citation: (Butt 2019)

Our metabolic functions (e.g. organs, glands, involuntary muscles) are influenced by the autonomic nervous system (ANS) via sympathetic and parasympathetic divisions. The vagus nerve, the 10th longest of the cranial nerves, is a major component of the parasympathetic nervous system and serves to maintain homeostasis providing bidirectional communication between the body and brain.  The neuroatanomy of the auricular branch of the vagus nerve (ABVN) offers insight for an understanding of the ef...


Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective. Citation: (Kaniusas 2019, 772)

Bioelectronic medicine progressively comes into focus as offering a non-pharmaceutical treatment option for various diseases. Here neuromodulation of the vagus nerve (VN) has gained a special interest. In a comprehensive review technical issues, modeling concepts, regulatory and safety requirements, and novel architectures of open and closed-loop aVNS paradigms, Kaniusas and his colleagues focus on the physiological role of VN including a biology-driven rationale for Auricular Vagus Nerve Sti...


Peripheral effects of vagus nerve stimulation on anxiety and extinction of conditioned fear in rats. Citation: (Noble 2019)

Vagus nerve stimulation (VNS) has been shown to enhance extinction of conditioned fear in rats. Previous findings support this finding. It is hypothesized that this is the result of enhanced consolidation of extinction memories through the promotion of plasticity in related neural pathways. There are other explanations as well. The work supports rapidly expanding research into VNS, both invasive VNS and transcutaneous VNS (which is most often applied at the ear, e.g. transcutaneous auricular ...


The Present and Future of Vagus Nerve Stimulation. Citation: (Yang 2019, 344-352)

Vagus nerve stimulation (VNS) is an adjunctive neuromodulation therapy that was approved in 1997 for the alleviation of seizures; however, efforts to control epilepsy by stimulating the vagus nerve have been studied for over 100 years. The ability for VNS to affect various brain areas, has a wide indication for various intractable epileptic syndromes and epilepsyrelated comorbidities. Moreover, recent studies have shown anti-inflammatory effects of VNS, and the indication is expanding beyond ...