Different Transcutaneous Auricular Vagus Nerve Stimulation Parameters Modulate the Anti-Inflammatory Effects on Lipopolysaccharide-Induced Acute Inflammation in Mice (citation: Go 2022)

Read more about a successful study to determine the effective anti-inflammation capacity of transcutaneous auricular vagus nerve stimulation (taVNS) through development of a stimulating electrode system of transcutaneous auricular VN. Citation: Go YY, Ju WM, Lee CM, Chae SW, Song JJ. Different Transcutaneous Auricular Vagus Nerve Stimulation Parameters Modulate the Anti-Inflammatory Effects on Lipopolysaccharide-Induced Acute Inflammation in Mice. Biomedicines. 2022;10(2):247. Published 2022...


Auricular Neuromodulation for Mass Vagus Nerve Stimulation: Insights From SOS COVID-19 a Multicentric, Randomized, Controlled, Double-Blind French Pilot Study

Acute inflammation can turn chronic, as shown in studies such as reported by Harvard Medical School in a special report on Fighting Inflammation: How to stop the damage before it compromises your health. In fact, an exacerbated inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is believed to be one of the major causes of the morbidity and mortality of the coronavirus disease 2019 (COVID-19). However, inflammation that turns chronic can become a re...


Experimental study on changes of histology and ultrastructure of the auricular stomach point in rabbits with acute and chronic gastritis. Citation: (Liu 2021)

Dr. Jihong Liu, MD, at the Preventative Treatment Center of the Foshan Hospital of Traditional Chinese Medicine in Foshan, China, et al. have studied the auricular stomach point of rabbits with acute and chronic gastritis to observe the changes in histological and ultrastructure of the auricular point against those in control groups. Results showed histological changes, including mast cells infiltration, hyperplasia of epidermis and dermis and loosed dense connective tissue, were observed in ...


Vagus Nerve Stimulation for Posttraumatic Stress Disorder in 2021 review by the Psychological Health Center of Excellence of the Department of Defense

The Psychological Health Center of Excellence of the Defense Health Agency in the Department of Defense has released a Psych Health Evidence Brief on the use of vagus nerve stimulation (VNS) for Posttraumatic Stress Disorder (PTSD). Although the 2021 brief falls short of recommending VNS for treatment of PTSD, it shows recognition of a treatment approach that is gaining rapid momentum even just since 2020.[1] In fact, transcutaneous auricular vagus nerve stimulation (taVNS) is treatment ap...


Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases. Citation: (Bonaz 2021)

A review of the potential of vagus nerve stimulation (VNS) for inflammatory bowel disease (IBD), concludes that targeting the anti-inflammatory properties of the vagus nerve with VNS could be of interest in the management of patients with IBD involving the digestive tract through a non-drug therapy. About 1.5 million Americans and 2.2 million people in Europe are affected by IBD. There is a rising incidence of IBD in Western countries, supporting the hypothesis that “Westernization” of our li...


Patient Feedback on the Effectiveness of Auricular Acupuncture on Pain in Routine Clinical Care: The Experience of 11,406 Veterans. Citation: (Zeliadt 2020, 101-107)

The American Veterans Health Administration (VHA) launched a national initiative to train providers in Battlefield Acupuncture (BFA) treatment as a non-pharmacological approach to pain management, and performed a research project over a 2 year period (2016-2018) to evaluate its effectiveness on immediate pain relief. This project took place at 57 VHA medical centers in the United States. A total of 11,406 veterans were treated with BFA at least once, in some cases 3 times.  More than 75% expe...


Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice. Citation: (Yap 2020)

Several studies investigating the use of transcutaneous vagus nerve stimulation (tVNS) for disorders tinnitus, migraine and pain show therapeutic effects similar to those produced by the more invasive direct vagus nerve stimulation (VNS). Although VNS is an FDA-approved therapy for the treatment of both depression and epilepsy, it is limited to being a second or third-line treatment option for severe, intervention-resistant cases, due to risks involved with device implantation. In contrast, t...


Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression

Review article on the potential of transcutaneous auricular vagus nerve stimulation (taVNS) in managing depression — and as it possibly relates to pain and other chronic conditions affected by negative emotional affect and psychological conditions such as depression.   Reference: Liu, CH., Yang, MH., Zhang, GZ. et al. Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression. J Neuroinflammation 17, 54 (2020). https://doi.org/10.1186/s1...


The anatomical basis for transcutaneous auricular vagus nerve stimulation. Citation: (Butt 2019)

Our metabolic functions (e.g. organs, glands, involuntary muscles) are influenced by the autonomic nervous system (ANS) via sympathetic and parasympathetic divisions. The vagus nerve, the 10th longest of the cranial nerves, is a major component of the parasympathetic nervous system and serves to maintain homeostasis providing bidirectional communication between the body and brain.  The neuroatanomy of the auricular branch of the vagus nerve (ABVN) offers insight for an understanding of the ef...


Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective. Citation: (Kaniusas 2019, 772)

Bioelectronic medicine progressively comes into focus as offering a non-pharmaceutical treatment option for various diseases. Here neuromodulation of the vagus nerve (VN) has gained a special interest. In a comprehensive review technical issues, modeling concepts, regulatory and safety requirements, and novel architectures of open and closed-loop aVNS paradigms, Kaniusas and his colleagues focus on the physiological role of VN including a biology-driven rationale for Auricular Vagus Nerve Sti...


Experimental Results in Auricular Medicine—A New Hypothesis. Citation: (Litscher 2018, 132)

This editorial proposes a multimodal concept for future research on the Vascular Autonomic Signal (VAS) through hypothesis concerning mechanisms of the VAS. Download the paper on Medicines (external link)  Litscher G, Yannacopoulos T, Kreisl P. Nogier Reflex: Physiological and Experimental Results in Auricular Medicine—A New Hypothesis. Medicines 2018;5(4):132. 


Tragus or cymba conchae? Investigating the anatomical foundation of transcutaneous auricular vagus nerve stimulation (taVNS). Citation: (Badran, 2018)

Badran et. al. provide commentary on the growing interest in modulating the auricular branch of the vagus nerve (ABVN). Researchers clearly want to know which ear target is optimal for taVNS e tragus or cymba conchae. Although the authors note discrepancies — identified by Burger and Verkuil in the investigation of a manuscript by Peuker and Filler describing vagus innervation of the ear — that they have found difficult to resolve, their commentary offers insights.[1] First, recognizing the i...