Paolo Cassano at the Massachusetts General Hospital Depression Clinical & Research Program in Boston, and respective colleagues at the Wellman Center for Photomedicine, LiteCure LLC, and Mount Sinai Hospital, have registered and completed a pilot study with ClinicalTrials.gov to confirm and extend preliminary data on Transcranial near-infrared radiation (NIR) is an innovative treatment for major depressive disorder (MDD). In a double-blind, randomized study of 6 sessions of NIR versus sham treatment on four patients with MDD, using a crossover design, the team investigated tolerability and efficacy of NIR in patients with MDD. Results showed post-treatment depression ratings were significantly reduced from baseline in the four MDD subjects, the treatment was well tolerated, and time to remission was consistent with other antidepressant treatments (6-7 weeks).
Laser is used to non-invasively deliver energy to cytochrome c oxidase. This stimulation of a key mitochondrial respiratory chain enzyme (COMPLEX IV, electron transfer chain) leads to increased adenosine triphosphate (ATP) production [1-3]. While several NIR wavelengths have been shown to benefit neuronal cell cultures, the most effective ones (830nm, 670 nm) paralleled the NIR and red action spectra of oxidized cytochrome c oxidase . Data suggest that coherent red light (670 nm diode laser) protects the viability of cell culture after oxidative stress, as indicated by increased mitochondrial membrane potentials . NIR also stimulates neurite out- growth mediated by nerve growth factor, and this effect could also have positive implications for axonal protection . Neuroprotective effects of incoherent red light, 670 nm light.
See the full journal article at Hindawi
P. Cassano, C. Cusin, D. Mischoulon, et al., “Near-infrared transcranial
radiation for major depressive disorder: Proof of concept study,” Psychiatry
Journal, vol. 2015, 2015.
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